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It was shown that long term oral intake of Danshen extract tablets had small effect within the plasma concentrations of theophylline. Table 1 summarizes the pharmacokinetic parameters of theophylline just before and soon after 14 days treatment with Danshen extract tablets.

37 and 4. 47 l h?1 and tmax Fingolimod was 1. 6 h and 1. 3 h, respectively, for 14 day Danshen extract tablet treatment and before comedication with Danshen extract tablets. Twelve subjects completed the study per protocol and all tolerated well the Danshen extract tablets and theophylline. Because many composite preparations containing danshen are available on market, Danshen extract tablets were selected as a test preparation in order to avoid the interference of other plant components. In this study, 14 days of treatment with Danshen extract tablets had no effect on the Cmax of theophylline. Moreover, none of the other pharmacokinetic parameters for theophylline were signi?cantly altered by concomitant administration of Danshen extract tablets.

The poor absorption of Tanshinone IIA may have been caused by its low aqueous solubility NSCLC and limited membrane permeability. The lipophilic components of Danshen extract have low bioavailability, therefore they have little effect on CYP1A2 which mainly locates on the hepatocyte after oral administration. Since theophylline is mainly metabolized by CYP1A2, the metabolism of theophylline is not likely to be in?uenced by long term oral administration of Danshen extract. In conclusion, long term oral administration of Danshen extract tablets did not change the basic pharmacokinetic parameters of theophylline. Thus, dose adjustment of theophylline may not be necessary in patients receiving concomitant Cell Cycle inhibitor therapy with Danshen extract tablets.

Similarly, in gene therapy every effort should be made to avoid immune responses prophylactically. In this review, we will focus on drug based strategies to avoid immune responses to the vector and/or the transgene following in vivo delivery of recombinant vectors.